anti- uPA antibody

Product Description

anti- uPA antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: PLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1(PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder(QPD)..

Immunogen: plasminogen activator, urokinase

Synonyms: ATF, PLAU, U plasminogen activator, uPA, URK

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP, IF

Recommended dilution: WB: 1:500-1:1000; IHC?1:20-1:200?IF: 1?20-1?200; IP: 1?500-1?2000

Image 1: Immunohistochemistry of paraffin-embedded human skin using FNab09267(uPA antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HeLa cells using FNab09267 (uPA antibody) at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab09267(uPA antibody) at dilution of 1:500

Gene ID: 5328

Research Area: Metabolism

Uniprot ID: P00749