Euro
British Pound
US Dollar
Product Description
anti- uPAR antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559).
Immunogen: plasminogen activator, urokinase receptor
Synonyms: CD87, MO3, PLAUR, U PAR, UPAR, URKR
Reactivity: Human, Mouse
Tested Application: ELISA, WB, IP
Recommended dilution: WB: 1:200-1:2000; IP: 1:200-1:1000
Image 1:
Image 2: .
Image 3:
Image 4: RAW264.7 cells were subjected to SDS PAGE followed by western blot with FNab09268(uPAR, PLAUR antibody) at dilution of 1:500
Research Area: Metabolism
Uniprot ID: Q03405
