anti- UPF1 antibody

Product Description

anti- UPF1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants..

Immunogen: UPF1 regulator of nonsense transcripts homolog (yeast)

Synonyms: ATP dependent helicase RENT1, FLJ43809, FLJ46894, HUPF1, KIAA0221, NORF1, pNORF1, RENT1, UPF1

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded human kidney slide using FNab09270( UPF1 Antibody) at dilution of 1:50

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09270(UPF1 antibody) at dilution of 1:1000

Gene ID: 5976

Research Area: Metabolism

Uniprot ID: Q92900