anti- UPF3A antibody

Product Description

anti- UPF3A antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation..

Immunogen: UPF3 regulator of nonsense transcripts homolog A(yeast)

Synonyms: HUpf3, HUPF3A, RENT3A, UPF3, UPF3A

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:5000; IHC?1:20-1:200?IF: 1?20-1?200

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab09271(UPF3A antibody) at dilution of 1:50

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Image 4: human testis tissue were subjected to SDS PAGE followed by western blot with FNab09271(UPF3A antibody) at dilution of 1:500

Gene ID: 65110

Research Area: Metabolism

Uniprot ID: Q9H1J1