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Product Description
anti- UPF3B antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core..
Immunogen: UPF3 regulator of nonsense transcripts homolog B(yeast)
Synonyms: HUPF3B, hUpf3p X, MRXS14, RENT3B, UPF3B, UPF3X
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC
Recommended dilution: WB: 1:500-1:5000; IHC?1:20-1:200
Image 1: Immunohistochemistry of paraffin-embedded human testis slide using FNab09272(UPF3B Antibody) at dilution of 1:50
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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09272(UPF3B antibody) at dilution of 1:2000
Gene ID: 65109
Research Area: Metabolism
Uniprot ID: Q9BZI7
