anti- USP10 antibody

Product Description

anti- USP10 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989)..

Immunogen: ubiquitin specific peptidase 10

Synonyms: Deubiquitinating enzyme 10, KIAA0190, Ubiquitin thiolesterase 10, UBPO, USP10

Reactivity: Human, Mouse

Tested Application: ELISA, IHC, IF

Recommended dilution: IHC: 1:50-1:200; IF: 1:20-1:100

Image 1: Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab10128 (USP10 Antibody) at dilution of 1:100.

Image 2: Immunofluorescence analysis of A549 cells using USP10 antibody (FNab10128). Blue: DAPI for nuclear staining..

Image 3:

Image 4:

Gene ID: 9100

Research Area: Metabolism

Uniprot ID: Q14694