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Product Description
anti- USP19 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation(ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol(E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains..
Immunogen: ubiquitin specific peptidase 19
Synonyms: Deubiquitinating enzyme 19, KIAA0891, Ubiquitin thiolesterase 19, USP19, ZMYND9
Reactivity: Human
Tested Application: ELISA, WB
Recommended dilution: WB: 1:500-1:2000
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Image 4: Hela cells were subjected to SDS PAGE followed by western blot with FNab09314(USP19 Antibody) at dilution of 1:1000
Research Area: Metabolism
Uniprot ID: O94966
