anti- VAMP8 antibody

Product Description

anti- VAMP8 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex(PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets(PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells(By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells(By similarity). Involved in the homotypic fusion of early and late endosomes(By similarity)..

Immunogen: vesicle-associated membrane protein 8(endobrevin)

Synonyms: EDB, Endobrevin, VAMP 8, VAMP8

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:1000

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Image 4: HL-60 cells were subjected to SDS PAGE followed by western blot with FNab09365(VAMP8 Antibody) at dilution of 1:300

Gene ID: 8673

Research Area: Metabolism

Uniprot ID: Q9BV40