Recombinant Human Asialoglycoprotein receptor 1 (ASGR1), partial

Product Description

Recombinant Human Asialoglycoprotein receptor 1 (ASGR1), partial is available at Gentaur for Next week Delivery.

Gene Name: ASGR1

Alternative Names : C-type lectin domain family 4 member H1Hepatic lectin H1;HL-1

Expression Region : 68-291aa

AA Sequence : EELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Sequence Info : Partial

Tag Info : N-terminal 6xHis-tagged

Theoretical MW : 29.7 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been roved. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell mbrane surface.

Function : Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Involvement in disease :

Subcellular location : Isoform H1a: Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Isoform H1b: Secreted

Protein Families :

Tissue Specificity : Expressed exclusively in hepatic parenchymal cells.

Paythway : Th17celldifferentiation

Uniprot ID : P07306