Recombinant Human B-cell lymphoma/leukemia 10 (BCL10)

Product Description

Recombinant Human B-cell lymphoma/leukemia 10 (BCL10) is available at Gentaur for Next week Delivery.

Gene Name: BCL10

Alternative Names : B-cell CLL/lymphoma 10;hCLAPCED-3/ICH-1 prodomain homologous E10-like regulator;CIPER;Cellular homolog of vCARMEN;cCARMENCellular-E10;c-E10Mammalian CARD-containing adapter molecule E10;mE10

Expression Region : 1-233aa

AA Sequence : MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ

Sequence Info : Full Length

Tag Info : N-terminal 6xHis-SUMO-tagged

Theoretical MW : 42.3 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Apoptosis

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Involved in adaptive immune response . Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 .

Function : Involved in adaptive immune response

Involvement in disease : Immunodeficiency 37 (IMD37); Lymphoma, mucosa-associated lymphoid type (MALTOMA)

Subcellular location : Cytoplasm, perinuclear region, Membrane raft

Protein Families :

Tissue Specificity : Ubiquitous.

Paythway : NF-kappaBsignalingpathway

Uniprot ID : O95999