Recombinant Human Beta-adrenergic receptor kinase 1 (GRK2), partial

Product Description

Recombinant Human Beta-adrenergic receptor kinase 1 (GRK2), partial is available at Gentaur for Next week Delivery.

Gene Name: GRK2

Alternative Names : G-protein coupled receptor kinase 2

Expression Region : 2-221aa

AA Sequence : ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC

Sequence Info : Partial

Tag Info : N-terminal 6xHis-tagged

Theoretical MW : 29.6 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Neuroscience

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of th. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Function : Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Involvement in disease :

Subcellular location : Cytoplasm, Cell membrane

Protein Families : Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily

Tissue Specificity : Expressed in peripheral blood leukocytes.

Paythway : Chemokinesignalingpathway

Uniprot ID : P25098