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Product Description
Recombinant Human Beta-defensin 103 protein (DEFB103A) (Active) is available at Gentaur for Next week Delivery.
Gene Name: DEFB103A,BD3,DEFB103,DEFB3;,DEFB103B
Alternative Names : Beta-defensin 3, DEFB-3, HBD3, hBD-3, Defensin, beta 103
Expression Region : 23-67aa
AA Sequence : GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
Sequence Info : Full Length of Mature Protein
Tag Info : Tag-Free
Theoretical MW : 5.2 kDa
Storage Buffer : Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl
Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-
Biological Activity : The ED50 as determined by anti-microbial activity against E.coli. is less than 30 ?g/ml, corresponding to a specific activity of ? 33.3 IU/mg.
Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.
Research Area : Microbiology
Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance : Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {ECO:0000269|PubMed:11085990}.
Function : Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.
Involvement in disease :
Subcellular location : Secreted
Protein Families : Beta-defensin family
Tissue Specificity : Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.
Paythway :
Uniprot ID : P81534
