Recombinant Human CD40 ligand (CD40LG), partial (Active)

Product Description

Recombinant Human CD40 ligand (CD40LG), partial (Active) is available at Gentaur for Next week Delivery.

Gene Name: CD40LG

Alternative Names : CD40 Ligand; CD40-L; T-Cell Antigen Gp39; TNF-Related Activation Protein; TRAP; Tumor Necrosis Factor Ligand Superfamily Member 5; CD154; CD40LG; CD40L; TNFSF5; TRAP

Expression Region : 113-261aa

AA Sequence : MQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 16.2 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 20 mM PB, 200 mM NaCl, 0.1 mM EDTA, pH 7.0

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by the dose-dependent stimulation of IL-12 & IL-8 induction by PMB cells is less than 20 ug/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.

Function : Cytokine that binds to CD40/TNFRSF5

Involvement in disease : Immunodeficiency with hyper-IgM, type 1 (HIGM1)

Subcellular location : Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted

Protein Families : Tumor necrosis factor family

Tissue Specificity : Specifically expressed on activated CD4+ T-lymphocytes.

Paythway : NF-kappaBsignalingpathway

Uniprot ID : P29965