Recombinant Human CD40 ligand(CD40LG), partial (Active)

Product Description

Recombinant Human CD40 ligand(CD40LG), partial (Active) is available at Gentaur for Next week Delivery.

Gene Name: CD40LG,CD40L,TNFSF5,TRAP

Alternative Names : CD40-L, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD antigen CD154

Expression Region : 113-261aa (C194W)

AA Sequence : MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 16.3 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.0

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 10-15 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269|PubMed:15193700}.; Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269|PubMed:15193700}.

Function : Cytokine that binds to CD40/TNFRSF5

Involvement in disease : Immunodeficiency with hyper-IgM, type 1 (HIGM1)

Subcellular location : Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted

Protein Families : Tumor necrosis factor family

Tissue Specificity : Specifically expressed on activated CD4+ T-lymphocytes.

Paythway : NF-kappaBsignalingpathway

Uniprot ID : P29965