Recombinant Human DnaJ homolog subfamily B member 2 (DNAJB2)

Product Description

Recombinant Human DnaJ homolog subfamily B member 2 (DNAJB2) is available at Gentaur for Next week Delivery.

Gene Name: DNAJB2

Alternative Names : DnaJ protein homolog 1Heat shock 40KDA protein 3Heat shock protein J1;HSJ-1

Expression Region : 2-324aa

AA Sequence : ASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGPFSELQNRGSRHSGPFFTFSSSFPGHSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVTSRSGGTQVQQTPASCPLDSDLSEDEDLQLAMAYSLSEMEAAGKKPAGGREAQHRRQGRPKAQHQDPGLGGTQEGARGEATKRSPSPEEKASRCLIL

Sequence Info : Full Length of Isoform 3

Tag Info : N-terminal 6xHis-SUMO-tagged

Theoretical MW : 51.4 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance :

Function : Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family

Involvement in disease : Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5)

Subcellular location : Isoform 2: Cytoplasm, Nucleus, SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane, Lipid-anchor, Cytoplasmic side

Protein Families :

Tissue Specificity : More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272).

Paythway : Proteinprocessinginendoplasmicreticulum

Uniprot ID : P25686