Recombinant Human Dystonin (DST), partial

Product Description

Recombinant Human Dystonin (DST), partial is available at Gentaur for Next week Delivery.

Gene Name: DST

Alternative Names : 230KDA bullous pemphigoid antigen230/240KDA bullous pemphigoid antigen;Bullous pemphigoid antigen 1;BPA;Bullous pemphigoid antigenDystonia musculorum proteinHemidesmosomal plaque protein

Expression Region : 1-195aa

AA Sequence : MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSG

Sequence Info : Partial of Isoform 3

Tag Info : N-terminal 6xHis-tagged

Theoretical MW : 23.7 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh.Isoform 3: plays a structural role in the assbly of hidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.Isoform 6: required for bundling actin filaments around the nucleus.Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.

Function : Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity).

Involvement in disease : Neuropathy, hereditary sensory and autonomic, 6 (HSAN6); Epidermolysis bullosa simplex, autosomal recessive 2 (EBSB2)

Subcellular location : Cytoplasm, cytoskeleton, Cell projection, axon, Note=Associates with intermediate filaments, actin and microtubule cytoskeletons, Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells (By similarity), Associated at the growing distal tip of microtubules, SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere, Z line, Cytoplasm, myofibril, sarcomere, H zone, Note=Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytoskeleton, Note=Colocalizes both cortical and cytoplasmic actin filaments, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, cytoskeleton, Cell junction, hemidesmosome, Note=Localizes to actin and intermediate filaments cytoskeletons (By similarity), Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins, Colocalizes with ITGB4 at the leading edge of migrating keratinocytes, SUBCELLULAR LOCATION: Isoform 6: Nucleus, Nucleus envelope, Membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein, Cytoplasm, cytoskeleton, Note=Localizes to actin and intermediate filaments cytoskeletons, Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells, Translocates to the nucleus (By similarity), Associates with actin cytoskeleton in sensory neurons, SUBCELLULAR LOCATION: Isoform 7: Cytoplasm, cytoskeleton, Cell projection, axon, Membrane

Protein Families :

Tissue Specificity : Isoform 1 is expressed in myoblasts (at protein level). Isoform 3 is expressed in the skin. Isoform 6 is expressed in the brain. Highly expressed in skeletal muscle and cultured keratinocytes.

Paythway :

Uniprot ID : Q03001