Recombinant Human Fibroblast growth factor 1 protein (FGF1) (Active)

Product Description

Recombinant Human Fibroblast growth factor 1 protein (FGF1) (Active) is available at Gentaur for Next week Delivery.

Gene Name: FGF1,FGFA

Alternative Names : FGF-1, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1

Expression Region : 1-155aa

AA Sequence : MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD

Sequence Info : Full Length

Tag Info : Tag-Free

Theoretical MW : 17.5 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4, with 2 mM EDTA, 0.5 mM DTT, 5 % Trehalose

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 × 106 IU/mg in the presence of 10 ?g/ml of heparin.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:8663044}.

Function : Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV

Involvement in disease :

Subcellular location : Secreted, Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytosol, Nucleus

Protein Families : Heparin-binding growth factors family

Tissue Specificity : Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

Paythway : Hipposignalingpathway

Uniprot ID : P05230