Recombinant Human Fractalkine protein (CX3CL1) (Active)

Product Description

Recombinant Human Fractalkine protein (CX3CL1) (Active) is available at Gentaur for Next week Delivery.

Gene Name: CX3CL1,FKN,NTT,SCYD1,A-152E5.2

Alternative Names : C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1,,

Expression Region : 210-150aa

AA Sequence : QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 8.6 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 5.0-10 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}.

Function : Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1

Involvement in disease :

Subcellular location : Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted

Protein Families : Intercrine delta family

Tissue Specificity : Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.

Paythway : Chemokinesignalingpathway

Uniprot ID : P78423