Recombinant Human Guanine nucleotide-binding protein G (s) subunit alpha isoforms short (GNAS)

Product Description

Recombinant Human Guanine nucleotide-binding protein G (s) subunit alpha isoforms short (GNAS) is available at Gentaur for Next week Delivery.

Gene Name: GNAS

Alternative Names : Adenylate cyclase-stimulating G alpha protein

Expression Region : 1-394aa

AA Sequence : MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL

Sequence Info : Full Length

Tag Info : N-terminal 6xHis-SUMO-tagged

Theoretical MW : 61.7 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) . Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP . GNAS functions downstream of several GPCRs, including beta-adrenergic receptors . Stimulates the Ras signaling pathway via RAPGEF2 .

Function : Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs)

Involvement in disease : Albright hereditary osteodystrophy (AHO); Pseudohypoparathyroidism 1A (PHP1A); McCune-Albright syndrome (MAS); Progressive osseous heteroplasia (POH); ACTH-independent macronodular adrenal hyperplasia 1 (AIMAH1); Pseudohypoparathyroidism 1B (PHP1B); GNAS hyperfunction (GNASHYP); Pseudohypoparathyroidism 1C (PHP1C)

Subcellular location : Cell membrane, Lipid-anchor

Protein Families : G-alpha family, G(s) subfamily

Tissue Specificity :

Paythway :

Uniprot ID : P63092