Recombinant Human Insulin-like growth factor I protein (IGF1) (Active)

Product Description

Recombinant Human Insulin-like growth factor I protein (IGF1) (Active) is available at Gentaur for Next week Delivery.

Gene Name: IGF1,IBP1

Alternative Names : IGF-I, MGF, Somatomedin-C

Expression Region : 49-118aa

AA Sequence : GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 7.7 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.0

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 × 105 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:24132240}.

Function : The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation

Involvement in disease : Insulin-like growth factor I deficiency (IGF1 deficiency)

Subcellular location : Secreted

Protein Families : Insulin family

Tissue Specificity :

Paythway : HIF-1signalingpathway

Uniprot ID : P05019