Recombinant Human Insulin-like growth factor II protein (PP1446), partial

Product Description

Recombinant Human Insulin-like growth factor II protein (PP1446), partial is available at Gentaur for Next week Delivery.

Gene Name: PP1446

Alternative Names : Somatomedin-AT3M-11-derived growth factor

Expression Region : 30-180aa

AA Sequence : ETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK

Sequence Info : Partial

Tag Info : N-terminal GST-tagged

Theoretical MW : 44.1 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Metabolism

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Function : The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable).

Involvement in disease : Silver-Russell syndrome (SRS); Growth restriction, severe, with distinctive facies (GRDF)

Subcellular location : Secreted

Protein Families : Insulin family

Tissue Specificity : Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.

Paythway : MAPKsignalingpathway

Uniprot ID : P01344