Recombinant Human Interleukin-1 beta protein (IL1B) (Active)

Product Description

Recombinant Human Interleukin-1 beta protein (IL1B) (Active) is available at Gentaur for Next week Delivery.

Gene Name: IL1B,IL1F2

Alternative Names : IL-1 beta,

Expression Region : 117-269aa

AA Sequence : APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIP VAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQ FPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 17.3 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of ? 1.0 × 109 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. {ECO:0000269|PubMed:3920526}.

Function : Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Involvement in disease :

Subcellular location : Cytoplasm, cytosol, Lysosome, Secreted, exosome, Secreted

Protein Families : IL-1 family

Tissue Specificity : Expressed in activated monocytes/macrophages (at protein level).

Paythway : MAPKsignalingpathway

Uniprot ID : P01584