Recombinant Human Interleukin-17F (IL17F) (Active)

Product Description

Recombinant Human Interleukin-17F (IL17F) (Active) is available at Gentaur for Next week Delivery.

Gene Name: IL17F

Alternative Names : Interleukin-17F; IL-17F; Cytokine ML-1; Interleukin-24; IL-24; IL17F; IL24

Expression Region : 31-163aa

AA Sequence : RKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 30.1 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 20 mM PB, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its ability to induce IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells is less than 40 ng/mL.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.

Function : Ligand for IL17RA and IL17RC

Involvement in disease : Candidiasis, familial, 6 (CANDF6)

Subcellular location : Secreted

Protein Families : IL-17 family

Tissue Specificity : Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Paythway : IL-17signalingpathway

Uniprot ID : Q96PD4