Recombinant Human Interleukin-2 (IL2), partial (Active)

Product Description

Recombinant Human Interleukin-2 (IL2), partial (Active) is available at Gentaur for Next week Delivery.

Gene Name: IL2

Alternative Names : Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2

Expression Region : 21-153aa(L80F & R81D & L85V & I86V & I92F)

AA Sequence : APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHFDPRDVVSNINVFVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 16.5 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 1xPBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined in a cell proliferation assay using CTLL?2 mouse cytotoxic T cells is less than 0.5 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system?belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells.

Function : Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Involvement in disease : A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Subcellular location : Secreted

Protein Families : IL-2 family

Tissue Specificity :

Paythway : Jak-STATsignalingpathway

Uniprot ID : P60568