Recombinant Human Lymphotoxin-alpha protein (LTA) (Active)

Product Description

Recombinant Human Lymphotoxin-alpha protein (LTA) (Active) is available at Gentaur for Next week Delivery.

Gene Name: LTA,TNFB,TNFSF1

Alternative Names : LT-alpha, Tumor necrosis factor ligand superfamily member 1

Expression Region : 35-205aa

AA Sequence : LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 18.7 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH7.4, with 0.02 % Tween-20

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 5 pg/ml, corresponding to a specific activity of ? 2.0 × 108 IU/mg in the presence of actinomycin D.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Function : Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Involvement in disease : Psoriatic arthritis (PSORAS)

Subcellular location : Secreted, Membrane

Protein Families : Tumor necrosis factor family

Tissue Specificity :

Paythway : NF-kappaBsignalingpathway

Uniprot ID : P01374