Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein (MANF) (Active)

Product Description

Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein (MANF) (Active) is available at Gentaur for Next week Delivery.

Gene Name: MANF,ARMET,ARP

Alternative Names : Arginine-rich protein,

Expression Region : 25-182aa

AA Sequence : LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 18.2 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 ?g/ml, corresponding to a specific activity of ? 50 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Neuroscience 

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. {ECO:0000250, ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914}.

Function : Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Involvement in disease :

Subcellular location : Secreted

Protein Families : ARMET family

Tissue Specificity :

Paythway :

Uniprot ID : P55145