Recombinant Human Neuroserpin protein (SERPINI1) (Active)

Product Description

Recombinant Human Neuroserpin protein (SERPINI1) (Active) is available at Gentaur for Next week Delivery.

Gene Name: SERPINI1,PI12

Alternative Names : Peptidase inhibitor 12, Serpin I1

Expression Region : 17-406aa

AA Sequence : TGATFPEEAI ADLSVNMYNR LRATGEDENI LFSPLSIALA MGMMELGAQG STQKEIRHSM GYDSLKNGEE FSFLKEFSNM VTAKESQYVM KIANSLFVQN GFHVNEEFLQ MMKKYFNAAV NHVDFSQNVA VANYINKWVE NNTNNLVKDL VSPRDFDAAT YLALINAVYF KGNWKSQFRP ENTRTFSFTK DDESEVQIPM MYQQGEFYYG EFSDGSNEAG GIYQVLEIPY EGDEISMMLV LSRQEVPLAT LEPLVKAQLV EEWANSVKKQ KVEVYLPRFT VEQEIDLKDV LKALGITEIF IKDANLTGLS DNKEIFLSKA IHKSFLEVNE EGSEAAAVSG MIAISRMAVL YPQVIVDHPF FFLIRNRRTG TILFMGRVMH PETMNTSGHD

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 44.7 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.5

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5 ?g/ml, corresponding to a specific activity of > 2000 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Neuroscience 

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

Function : Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin

Involvement in disease : Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)

Subcellular location : Secreted, Cytoplasmic vesicle, secretory vesicle lumen, Perikaryon

Protein Families : Serpin family

Tissue Specificity : Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919).

Paythway :

Uniprot ID : Q99574