Recombinant Human Neurotrophin-3 (NTF3) (Active)

Product Description

Recombinant Human Neurotrophin-3 (NTF3) (Active) is available at Gentaur for Next week Delivery.

Gene Name: NTF3

Alternative Names : Neurotrophin-3; NT-3; HDNF; Nerve Growth Factor 2; NGF-2; Neurotrophic Factor; NTF3

Expression Region : 139-257aa

AA Sequence : YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 13.6 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 20 mM PB, 250 mM NaCl, pH 7.2

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its ability to bind Human NTRK2 in functional ELISA is less than 10 ug/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Neuroscience

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors and is structurally related to ?-NGF, BDNF and NT-4. The NT3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT3.The amino acid sequences of mature human, murine and rat NT-3 are identical. NT-3 selectively promotes the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems.

Function : Seems to promote the survival of visceral and proprioceptive sensory neurons.

Involvement in disease :

Subcellular location : Secreted

Protein Families : NGF-beta family

Tissue Specificity : Brain and peripheral tissues.

Paythway : MAPKsignalingpathway

Uniprot ID : P20783