Recombinant Human Noggin protein (NOG) (Active)

Product Description

Recombinant Human Noggin protein (NOG) (Active) is available at Gentaur for Next week Delivery.

Gene Name: NOG

Alternative Names :

Expression Region : M+28-232aa

AA Sequence : M+QHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 46.3 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of ? 3.3 × 105 IU/mg in the presence of 5 ng/ml rHuBMP-4.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Stem Cells 

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273}.

Function : Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6

Involvement in disease : Symphalangism, proximal 1A (SYM1A); Multiple synostoses syndrome 1 (SYNS1); Tarsal-carpal coalition syndrome (TCC); Stapes ankylosis with broad thumb and toes (SABTS); Brachydactyly B2 (BDB2)

Subcellular location : Secreted

Protein Families : Noggin family

Tissue Specificity :

Paythway : TGF-betasignalingpathway

Uniprot ID : Q13253