Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1), partial

Product Description

Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1), partial is available at Gentaur for Next week Delivery.

Gene Name: SERPINE1

Alternative Names : Endothelial plasminogen activator inhibitorSerpin E1

Expression Region : 24-401aa

AA Sequence : VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVME

Sequence Info : Partial

Tag Info : N-terminal 6xHis-tagged

Theoretical MW : 46.7 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cardiovascular

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Function : Serine protease inhibitor. Inhibits TMPRSS7

Involvement in disease : Plasminogen activator inhibitor-1 deficiency (PAI-1D)

Subcellular location : Secreted

Protein Families : Serpin family

Tissue Specificity : Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.

Paythway : HIF-1signalingpathway

Uniprot ID : P05121