Recombinant Human Platelet-derived growth factor subunit B protein (PDGFB) (Active)

Product Description

Recombinant Human Platelet-derived growth factor subunit B protein (PDGFB) (Active) is available at Gentaur for Next week Delivery.

Gene Name: PDGFB,PDGF2,SIS

Alternative Names : PDGF subunit B, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis, Becaplermin

Expression Region : 82-190aa

AA Sequence : M+SLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 24.8 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of ? 3.3 × 105 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.

Function : Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin

Involvement in disease : Basal ganglia calcification, idiopathic, 5 (IBGC5)

Subcellular location : Secreted

Protein Families : PDGF/VEGF growth factor family

Tissue Specificity : Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.

Paythway : Jak-STATsignalingpathway

Uniprot ID : P01127