Recombinant Human Pro-interleukin-16 (IL16) (Active)

Product Description

Recombinant Human Pro-interleukin-16 (IL16) (Active) is available at Gentaur for Next week Delivery.

Gene Name: IL16

Alternative Names : Pro-Interleukin-16; Interleukin-16; IL-16; Lymphocyte Chemoattractant Factor; LCF; IL16

Expression Region : 1-130aa

AA Sequence : MPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS

Sequence Info : Full Length of AAC12732.1

Tag Info : Tag-Free

Theoretical MW : 13.4 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 20 mM PB, 150 mM NaCl, pH 7.0

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its to chemoattract human CD4+ T-lymphocytes using a concentration range of 10.0-100.0 ng/ml is typically 0.1 ug/mL.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.

Function :

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Uniprot ID : AAC12732.1