Recombinant Human Single-stranded DNA cytosine deaminase (AICDA)

Product Description

Recombinant Human Single-stranded DNA cytosine deaminase (AICDA) is available at Gentaur for Next week Delivery.

Gene Name: AICDA

Alternative Names : Activation-induced cytidine deaminase (AID) (Cytidine aminohydrolase)

Expression Region : 1-198aa

AA Sequence : MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL

Sequence Info : Full Length

Tag Info : N-terminal 10xHis-tagged and C-terminal Myc-tagged

Theoretical MW : 28.0 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Epigenetics and Nuclear Signaling

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes by deaminating C to U during transcription of Ig-variable and Ig-switch region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses . May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

Function : Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

Involvement in disease : Immunodeficiency with hyper-IgM 2 (HIGM2)

Subcellular location : Nucleus, Cytoplasm

Protein Families : Cytidine and deoxycytidylate deaminase family

Tissue Specificity : Strongly expressed in lymph nodes and tonsils.

Paythway :

Uniprot ID : Q9GZX7