Recombinant Human Spermatogenesis-defective protein 39 homolog (SPE39)

Product Description

Recombinant Human Spermatogenesis-defective protein 39 homolog (SPE39) is available at Gentaur for Next week Delivery.

Gene Name: VIPAS39

Alternative Names : VPS33B-interacting protein in apical-basolateral polarity regulatorVPS33B-interacting protein in polarity and apical restriction

Expression Region : 1-493aa

AA Sequence : MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDFVDDDDDDDLERVSWSGEPVGSISWSIRETAGNSGSTHEGREQLKSRNSFSSYAQLPKPTSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDTVRRLRKGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPDKRKEFLKTCVGLPFSAEDSAHIQDHYTLLERQIIIEANDRHLESAGQTEIFRKHPRKASILNMPLVTTLFYSCFYHYTEAEGTFSSPVNLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNNAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTYRDLKDRQQLLAYRSKVDKGSAEEEKIDALLSSSQIRWKN

Sequence Info : Full Length

Tag Info : N-terminal 6xHis-SUMO-tagged

Theoretical MW : 73 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Others

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : May play a role in vesicular trafficking during spermatogenesis . Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in epithelial polarization through stabilization of apical mbrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin.

Function : Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B

Involvement in disease : Arthrogryposis, renal dysfunction and cholestasis syndrome 2 (ARCS2)

Subcellular location : Cytoplasm, Cytoplasmic vesicle, Early endosome, Recycling endosome, Late endosome

Protein Families : SPE39 family

Tissue Specificity :

Paythway :

Uniprot ID : Q9H9C1