Recombinant Human Thymic stromal lymphopoietin protein (TSLP) (Active)

Product Description

Recombinant Human Thymic stromal lymphopoietin protein (TSLP) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TSLP

Alternative Names :

Expression Region : 29-159aa

AA Sequence : M+YDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK QQ

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 15.1 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150 mM NaCl

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a cell proliferation assay using human IL-7R? and human TSLP R co-transfected murine BaF3 pro-B cells is less than 0.3 ng/ml, corresponding to a specific activity of ? 3.3 × 106 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:0000269|PubMed:11418668, ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:17242164}.; Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin. {ECO:0000269|PubMed:24850429}.

Function : Isoform 1

Involvement in disease :

Subcellular location : Secreted

Protein Families :

Tissue Specificity : Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.

Paythway : Jak-STATsignalingpathway

Uniprot ID : Q969D9