Recombinant Human Trefoil factor 1 protein (TFF1) (Active)

Product Description

Recombinant Human Trefoil factor 1 protein (TFF1) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TFF1,BCEI,PS2

Alternative Names : Breast cancer estrogen-inducible protein, Polypeptide P1.A, hP1.A, Protein pS2,

Expression Region : 25-84aa

AA Sequence : EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF

Sequence Info : Full Length of Mature Protein

Tag Info : Tag-Free

Theoretical MW : 6.7 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by a chemotaxis bioassay using human MCF-7 cells is less than 10 ?g/ml, corresponding to a specific activity of ? 100 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Signal Transduction

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}.

Function : Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.

Involvement in disease :

Subcellular location : Secreted

Protein Families :

Tissue Specificity : Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).

Paythway : Estrogensignalingpathway

Uniprot ID : P04155