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Product Description
Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial (Active) is available at Gentaur for Next week Delivery.
Gene Name: TNFSF10
Alternative Names : Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL
Expression Region : 115-281aa
AA Sequence : RERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Sequence Info : Partial
Tag Info : Tag-Free
Theoretical MW : 19.5 kDa
Storage Buffer : Lyophilized from a 0.2 ?m Filtered 150 mM NaCl
Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-
Biological Activity : The ED50 as determined in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D is less than 50 ng/ml.
Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.
Research Area : Cancer
Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance : Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a TNF homology domain (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
Function : Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG
Involvement in disease :
Subcellular location : Membrane, Single-pass type II membrane protein
Protein Families : Tumor necrosis factor family
Tissue Specificity : Widespread; most predominant in spleen, lung and prostate.
Paythway : Apoptosis
Uniprot ID : P50591
