Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15) (Active)

Product Description

Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TNFSF15,TL1,VEGI

Alternative Names : TNF ligand-related molecule 1,

Expression Region : 72-251aa

AA Sequence : LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VRQTPTQHFK NQFPALHWEH ELGLAFTKNR MNYTNKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQAGRP NKPDSITVVI TKVTDSYPEP TQLLMGTKSV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 20.5 kDa

Storage Buffer : Lyophilized from a 0.2 µm filtered PBS, pH 7.4, with 0.02% Tween-20

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20 ng/ml, corresponding to a specific activity of ? 5.0 × 104 IU/mg.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}.

Function : Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Involvement in disease :

Subcellular location : Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted

Protein Families : Tumor necrosis factor family

Tissue Specificity : Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Paythway :

Uniprot ID : O95150