Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18) (Active)

Product Description

Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TNFSF18,AITRL,GITRL,TL6,UNQ149/PRO175

Alternative Names : Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, hGITRL

Expression Region : 74-199aa

AA Sequence : ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 14.3 kDa

Storage Buffer : Lyophilized from a 0.2 m filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10 ng/ml.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.

Function : Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1

Involvement in disease :

Subcellular location : Cell membrane, Single-pass type II membrane protein

Protein Families : Tumor necrosis factor family

Tissue Specificity : Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Paythway :

Uniprot ID : Q9UNG2