Recombinant Human Tumor necrosis factor receptor superfamily member 10B protein (TNFRSF10B) (Active)

Product Description

Recombinant Human Tumor necrosis factor receptor superfamily member 10B protein (TNFRSF10B) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TNFRSF10B,DR5,KILLER,TRAILR2,TRICK2,ZTNFR9,UNQ160/PRO186

Alternative Names : Death receptor 5, TRAIL receptor 2, TRAIL-R2, CD antigen CD262,

Expression Region : 52-183aa

AA Sequence : ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 14.8 kDa

Storage Buffer : Lyophilized from a 0.2µm filtered PBS, pH 7.4

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : rHusTRAIL-R2 reduced the production of LPS- induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed.

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Cancer

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.

Function : Receptor for the cytotoxic ligand TNFSF10/TRAIL

Involvement in disease : Squamous cell carcinoma of the head and neck (HNSCC)

Subcellular location : Membrane, Single-pass type I membrane protein

Protein Families :

Tissue Specificity : Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

Paythway : p53signalingpathway

Uniprot ID : O14763