Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein (TNFRSF11B) (Active)

Product Description

Recombinant Human Tumor necrosis factor receptor superfamily member 11B protein (TNFRSF11B) (Active) is available at Gentaur for Next week Delivery.

Gene Name: TNFRSF11B,OCIF,OPG

Alternative Names : Osteoclastogenesis inhibitory factor,

Expression Region : 22-194aa

AA Sequence : ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK

Sequence Info : Partial

Tag Info : Tag-Free

Theoretical MW : 19.7 kDa

Storage Buffer : Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA

Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-

Biological Activity : The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of ? 1.0 × 105 IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Immunology

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.

Function : Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Involvement in disease : Paget disease of bone 5, juvenile-onset (PDB5)

Subcellular location : Secreted

Protein Families :

Tissue Specificity : Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Paythway : Osteoclastdifferentiation

Uniprot ID : O00300