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Product Description
Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein (TNFRSF17), partial (Active) is available at Gentaur for Next week Delivery.
Gene Name: TNFRSF17,BCM,BCMA
Alternative Names : B-cell maturation protein,
Expression Region : 5-54aa
AA Sequence : AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
Sequence Info : Partial
Tag Info : Tag-Free
Theoretical MW : 5.4 kDa
Storage Buffer : Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA
Endotoxin Level : Less than 1.0 EU/µg as determined by LAL method.-
Biological Activity : The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of ? 2.5 × 104 IU/mg in the presence of 100 ng/ml human APRIL.
Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.
Research Area : Cancer
Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance : Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
Function : Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Involvement in disease : A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Subcellular location : Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein
Protein Families :
Tissue Specificity : Expressed in mature B-cells, but not in T-cells or monocytes.
Paythway :
Uniprot ID : Q02223
