Recombinant Mouse Bloom syndrome protein homolog (Blm), partial

Product Description

Recombinant Mouse Bloom syndrome protein homolog (Blm), partial is available at Gentaur for Next week Delivery.

Gene Name: Blm

Alternative Names : RecQ helicase homolog

Expression Region : 684-859aa

AA Sequence : INAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSFDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQ

Sequence Info : Partial

Tag Info : N-terminal 10xHis-tagged and C-terminal MYC-tagged

Theoretical MW : 24.7 kDa

Storage Buffer : Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Endotoxin Level : Not tested-

Biological Activity : Not tested

Storage : Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Research Area : Neuroscience

Restriction : For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Relevance : Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE)

Function : ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction

Involvement in disease :

Subcellular location : Nucleus

Protein Families : Helicase family, RecQ subfamily

Tissue Specificity : Highly expressed in testis 12-14 days after birth (corresponding to the pachytene phase) and at much lower levels in brain, heart, liver, lung, thymus, kidney and spleen (PubMed:9840919, PubMed:27010503). Expressed in bone marrow (PubMed:27010503).

Paythway :

Uniprot ID : O88700