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    • Protein
    • HSP90 alpha Protein
  • HSP90 alpha Protein
  • HSP90 alpha Protein

    HSP90 alpha Protein

    Stress Marq Biosciences

    MSRP:
    Now: €175.00
    (You save )
    (2 reviews) Write a Review
    SKU:
    SPR-101A
    Availability:
    Next week
    Shipping:
    Calculated at Checkout
    Size:
    50 µg
    Species:
    Human
    Specificity:
    ~90 kDa
    Conjugate:
    No tag
    Storage Temperature:
    -20ºC
    Purity:
    >90%

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    Product Description

    HSP90 alpha Protein is available at Gentaur for  Next Week Delivery.

    Description: Human Recombinant HSP90 alpha Protein.

    Alternative Name(s): HSP86 Protein, HSP89A Protein, HSP90A Protein, HSP90AA1 Protein, HSPC1 Protein, HSPCA Protein, HSPCAL3 Protein, HSP90alpha Protein.

    Research Area(s): Cancer | Heat Shock | Cell Signaling | Protein Trafficking | Chaperone Proteins | Cancer | Tumor Biomarkers

    Nature: Recombinant

    Accession Number: NP_001017963.2

    Gene ID: 3320

    Swiss-Prot: P07900 

    Applications Species: WB | SDS-PAGE | ATPase Activity Assay | Surface Plasmon Resonance (SPR) | DARTs Assay (Drug Affinity Responsive Target Stability Assay) | SB (Skin Blotting) 

    Biological Activity: 

    Expression System: E. coli

    Protein Length: Full Length

    Amino Acid Sequence:

    Purification: Affinity Purified

    Storage Buffer: 50mM Tris/HCl pH7.5, 5mM Bme, 0.3M NaCl, 10% glycerol

    Concentration: Lot/batch specific. See included datasheet.

    Shipping Temperature: Blue Ice or 4ºC

    Other relevant information:

    Certificate of Analysis: This product has been certified >90% pure using SDS­PAGE analysis. 

    Cellular Localization: Cytoplasm | Melanosome

    Scientific Background: HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

    References:

     1. Arlander S.J.H., et al. (2003) J Biol Chem. 278: 52572-52577.
    2. Pearl H., et al. (2001) Adv Protein Chem. 59:157-186.
    3. Neckers L., et al. (2002) Trends Mol Med. 8:S55-S61.
    4. Pratt W., Toft D. (2003) Exp Biol Med. 228:111-133.
    5. Pratt W., Toft D. (1997) Endocr Rev. 18: 306–360.
    6. Pratt W.B. (1998) Proc Soc Exptl Biol Med. 217: 420–434.
    7. Whitesell L., et al. (1994) Proc Natl Acad Sci USA. 91: 8324– 8328.

    Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

    PubMed ID: 28558721

    Published Application: Functional Assay|DARTs Assay|Functional Assay|ATPase activity assay|Surface Plasmon Resonance Spectroscopy|ATPase activity assay|ATPase activity assay|Western Blot Control

    Published Species Reactivity: Human/Mouse

    Product Videos

    Custom Field

    Size 50 µg
    Species Human
    Specificity ~90 kDa
    Conjugate No tag
    Storage Temperature -20ºC
    Purity >90%

    Product Reviews

    Write a Review

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    HSP90 alpha Protein
    Stress Marq Biosciences
    HSP90 alpha Protein

    2 Reviews Hide Reviews Show Reviews

    • 5
      HSP90 alpha Protein

      Posted by Alan on 11th Aug 2021

      I am very satisfied with this product. It helped me with my research. Also the delivery was very fast.

    • 5
      HSP90 alpha Protein

      Posted by PaulR on 9th Aug 2021

      I ordered this product by Stress MarQ Bioscences few days ago. I am very pleased with it. I came to my laboratory like two days after I ordered it.

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