anti- Acetylated tubulin(Lys40) antibody

Product Description

anti- Acetylated tubulin(Lys40) antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin..

Immunogen: tubulin, alpha 1a

Synonyms: Acetylated alpha tubulin, Acetylated tubulin, acetylated-a-tubulin, acetyl-a-tubulin, alpha tubulin, Alpha tubulin 3, tubulin,TUBA1A

Reactivity: Human, Mouse, Rat, Dog

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:5000; IF: 1:20-1:200; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab00082(Acetylated tubulin(Lys40) Antibody) at dilution of 1:50

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Image 4: L02 cells were subjected to SDS PAGE followed by western blot with FNab00082(Acetylated tubulin(Lys40) Antibody) at dilution of 1:1000

Gene ID: 7846

Research Area: Metabolism

Uniprot ID: Q71U36