anti- AFF1-Specific antibody

Product Description

anti- AFF1-Specific antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants..

Immunogen: AF4/FMR2 family, member 1

Synonyms: AFF1, MLLT2, AF4 MLL, PBM1, AF 4

Reactivity: Human, rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

Image 1: Immunohistochemistry of paraffin-embedded human placenta tissue slide using FNab00195(AFF1 Antibody) at dilution of 1:100

Image 2: Immunofluorescence analysis of U2OS cells using FNab00195(AFF1-Specific antibody)..

Image 3:

Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab00195(AFF1-Specific antibody) at dilution of 1:1000

Gene ID: 4299

Research Area: Metabolism

Uniprot ID: P51825