anti- AGAP2 antibody

Product Description

anti- AGAP2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion..

Immunogen: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Synonyms: AGAP 2, AGAP2, Centaurin gamma 1, CENTG1, Cnt g1, FLJ16430, GGAP2, KIAA0167, PIKE

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab00205(AGAP2 antibody) at dilution of 1:100

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab00205(AGAP2 antibody) at dilution of 1:500

Gene ID: 116986

Research Area: Metabolism

Uniprot ID: Q99490