anti- ALDH2 antibody

Product Description

anti- ALDH2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms..

Immunogen: aldehyde dehydrogenase 2 family (mitochondrial)

Synonyms: ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded rat liver using FNab00291(ALDH2 antibody) at dilution of 1:100

Image 2: .

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Image 4: mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab00291(ALDH2 antibody) at dilution of 1:1000

Gene ID: 217

Research Area: Metabolism

Uniprot ID: P05091