anti- ALKBH1 antibody

Product Description

anti- ALKBH1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Dioxygenase that acts as a DNA demethylase(PubMed:18603530). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:18603530). Specifically demethylates DNA methylated on the 6th position of adenine(N(6)-methyladenosine) DNA. N(6)-methyladenosine(m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing(By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity(PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites(PubMed:19959401). DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product(PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation(By similarity)..

Immunogen: alkB, alkylation repair homolog 1(E. coli)

Synonyms: ABH, ABH1, alkB, ALKBH, ALKBH1, DNA lyase ABH1, hABH

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab00311(ALKBH1 Antibody) at dilution of 1:50

Image 2: .

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Image 4: human placenta tissue were subjected to SDS PAGE followed by western blot with FNab00311(ALKBH1 antibody) at dilution of 1:500

Gene ID: 238

Research Area: Metabolism

Uniprot ID: Q13686