anti- AMFR antibody

Product Description

anti- AMFR antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor..

Immunogen: autocrine motility factor receptor

Synonyms: AMF receptor, isoform 2, AMFR, GP78, RING finger protein 45, RNF45

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution: WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200; IP: 1:200-1:2000

Image 1: Immunohistochemistry of paraffin-embedded human ovary using FNab00358(AMFR antibody) at dilution of 1:100

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00358(AMFR antibody) at dilution of 1:800

Gene ID: 267

Research Area: Metabolism

Uniprot ID: Q9UKV5